[White Paper] Live-Cell Analysis for Neuroscientists

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The last few decades have witnessed remarkable developments in the field of neuroscience. Recent advances in stem cell technologies offer an exciting promise where researchers can use human induced pluripotent stem cells (iPSCs) to create patient-specific advanced cell models for neuroscience. To fulfill this promise, considerable work is required to optimize the reprogramming and differentiation methods and to build and validate cellular bioassays that are representative of native human (patho) physiology. Accordingly, phenotypic measurements that inform of functional outcomes and long-term plastic changes will be hugely useful in this regard. In this white paper: - We discuss phenotypic measurements from a perspective of long-term live-cell analysis - Describe a suite of neurobiology applications that are amenable for studies in human iPSCs as well as primary cell models