Integrated and Stand-Alone Analyzers for Key Cell Culture Process Parameters
Ambr® systems have been developed with compatibility to a range of bioprocess analyzer technologies. This can be via integration to the Ambr® system, or via automated transfer of bioreactor sample data and return of analytical results.
Integrated analyzers allow routine measurement of key cell culture process parameters including cell viability, viable cell density and metabolite levels. Analyzers with data-connectivity provide critical quality attribute (CQA) information including product titer, glycosylation levels and cell culture media composition.
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Integration of proven technologies into Ambr® systems
Stand-alone analyzers with data connection to Ambr® systems
Ambr® 15 and Ambr® 250 High Throughput systems support a wide range of bioprocess analyzers.
Ambr® Analysis Module
Octet® BLI
BioAccord™
BioProfile® FLEX2
Vi-CELL BLU Analyzer or Cedex HiRes
Raman Rxn2* or HyperFLUX PRO*
Primary Application
pH calibration
Titer | binding kinetics
Protein | subunit measurement
Metabolite analysis
Viable cell count
Scale down model building
Secondary Application
Spectroscopy
Glycan analysis
Media analysis
Process transfer across scales
Connects with Ambr® 15
Ambr® 250 High Throughput
Direct Integration
*
Data-Connectivity
*Analyzer connected via the Ambr® Analysis Module
Ambr® Analysis Module automates pH sensor calibration and BioPAT Spectro applications.
Fully integrated into the Ambr® system, bioreactor samples are pipetted to the Analysis Module and results returned to the Ambr® software alongside bioreactor process data.
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The Raman Rxn2 automates Raman spectroscopy.
Raman Rxn2 integration is achieved via the BioPAT® Spectro option available for the Ambr® Analysis Module, which transfers bioreactor samples to a flow cell and results returned to the Ambr® software alongside bioreactor process data.
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The HyperFlux PRO 785 automates Raman spectroscopy.
HyperFlux PRO 785 integration is achieved via the BioPAT® Spectro option available for the Ambr® Analysis Module, which transfers bioreactor samples to a flow cell and results returned to the Ambr® software alongside bioreactor process data.
The FLEX2 automates metabolite analysis.
Fully integrated into the Ambr® system, the FLEX2 manages bioreactor samples processing and returns metabolite data to the Ambr® software alongside bioreactor process data.
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The Cedex HiRes automates viable cell counting.
Fully integrated into the Ambr® system, bioreactor samples are pipetted to the Cedex HiRes and results returned to the Ambr® software alongside bioreactor process data.
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The Vi-CELL BLU Analyzer automates viable cell counting.
Fully integrated into the Ambr® system, bioreactor samples are pipetted to the Vi-CELL BLU Analyzer for analysis and results returned to the Ambr® software alongside bioreactor process data.
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The Octet® BLI automates titre and glycan analysis.
Octet® BLI support is achieved via data interfaces facilitating transfer of bioreactor sample data to the analyzer and return of results to the Ambr®. Samples are manually transported between the systems.
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The BioAccord™ allows multi-attribute analysis of biological molecules.
BioAccord™ support is achieved via data interfaces facilitating transfer of bioreactor sample data to the analyzer and return of results to the Ambr®. Samples are manually transported between the systems.
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Standalone application designed for use with data from Ambr® systems to simplify the workflow for cell line screening and ranking.
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The fastest and most cost-efficient way to design effective experiments, increase productivity and de-risk projects.
Automated microbioreactor system for cell line development and process optimization, with 24 or 48 single-use 10-15mL microbioreactors.
Explore Ambr® 15
High throughput, automated bioreactor system for process development with 12 or 24 single-use 100–250mL mini bioreactors.
Explore Ambr® 250 High Throughput
A range of Analytics and Sensors for Uni-/ Multi-variate Data Gathering: Real Time Monitoring & Control.
Explore Biostat STR®
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