Biosealer® TC Aseptic Sealing Device
Automated Aseptic Thermoplastic Tubing Disconnection
Progressive biomanufacturing processes require advanced tools to reliably disconnect components. The Biosealer® Total Containment (TC) is an automated heat sealer for disconnecting thermoplastic tubing in an aseptic operation maintaining sterile fluid paths. The Biosealer® TC handles disconnections between disposable assemblies used in biopharmaceutical manufacturing processes and individual components of assemblies, even in non-sterile environments, while maintaining the product’s sterility.
Preset for sealing up to 6 sizes of the industry’s 5 most-used TPE tubing types*
The Biosealer® TC simplifies heat-sealing with a user-friendly portable design, highly stable thermal seals and a new level of flexibility. See the video to learn how the Biosealer® TC enhances thermoplastic tube-sealing.
Consult our Experts
The Biosealer® TC automated sealing device provides a simple, flexible, and fast solution for making sterile disconnections across all biopharmaceutical manufacturing processes. It can be used on disposable bags, unit operations and single-use tubing assemblies and can seal wet, dry or liquid-filled tubing.
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Intuitive user interface
Variety of qualified materials
Compatible with Tuflux® TPE, C-Flex® 374, AdvantaFlex®, Sanipure™ BDF™ and PharMed® BPT.
Variety of tube sizes and conditions
Has 1/8" × 1/4" up to 3/4" × 1" (ID × OD) capability, including liquid-filled conditions, no accessory needed.
The Biosealer® TC is lightweight and can be operated on a table or while hanging. Plus, the Biosealer® TC is portable and can be moved to where the sterile disconnection is desired.
Stable sealing
The Biosealer® TC offers a wide 20 mm seal for more robust disconnection. In addition, a cutting guideline embedded into the seal ensures operators can make a clean cut with scissors.
Insert TPE Tubing
Insert the TPE tubing in the device where the sterile disconnection is desired.
Press Start
One click on the touch screen is sufficient to start the sealing process. Just follow the instructions displayed.
Remove TPE Tubing
When the sealing process is complete, the lid automatically reopens.
Cut the Sealed TPE Tubing
After visual inspection of the sealing, use scissors to cut through the guideline on the sealed tubing. Done!
Biosealer® TC can seal wet, dry or liquid-filled tubing in non-classified and classified environments while maintaining product sterility.
From small-scale upstream processes to final filling applications in large commercial productions, the Biosealer® TC adapts to changing disconnection needs.
Create sterile seals for cell line development, cell and gene therapeutics and the production of mAbs, vaccines, and biosimilars.
Enhanced portability ensures the sealer can be moved to the process area where the sterile disconnection is desired.
Intuitive user interface to easily operate the device with integrated flip function.
Extended flexibility to cover a wide range of tubing material and diameters.
Protective cover to ensure stable and consistent operation.
Maximize sealing ability and smooth operations with useful accessories. Regular Sartorius service maintains peak performance.
The Biosealer® TC is a robust, flexible and easy-to-use device that generates sterile TPE tubing disconnections.
Ensure top Biosealer® performance with a temperature calibration kit. Enhance the device’s portability with a 3 m extension cable.
See how Sartorius services help support maintenance and longevity of your Research & Biomanufacturing Equipment while ensuring minimal downtime.
Sartorius Provides Complete Tube Sealing and Welding Solutions.
Benefit from low extractable profiles for both silicone and TPE tubing to transfer critical fluids across process steps.
The Biowelder® TC is an automated device for connecting thermoplastic tubing in a sterile welding operation.
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Clipster® is a single-use solution for disconnecting tubing at any stage in the process while maintaining sterility.
Installed on an array of tube materials, Quickseal® provides reliable and rapid aseptic tube disconnection.
*Including Tuflux® TPE, C-Flex® 374, AdvantaFlex®, SaniPure™ BDF ™ and PharMed® BPT . C-Flex®, SaniPure™ and PharMed® are registered trademarks of Saint-Gobain Performance Plastics Corporation. AdvantaFlex® is registered trademark of AdvantaPure.
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