A consistent supply of high-quality buffers is essential for downstream processing. Tailored buffers may increase yield and efficiency. Sartorius’ global manufacturing facilities are fully comply with the highest quality and regulatory standards and provide a reliable and uninterrupted supply of powder and liquid buffers in your preferred packaging. Whether you need a standard buffer or a customized solution, Sartorius has an experienced team to guide your selection across your process.
Flexsafe® Pro Mixer technology delivers high performance mixing using WFI-quality water for powder dissolution
Sartorius filters & cross flow cassettes are used with regular downstrem buffers (PBS, NaCl, acetate, tris) & WFI-quality water for flushing, regeneration, polishing and absorption
BioSMB and Sartobind® portfolios are used with elution and equilibration buffers for capturing and flushing
Flexact® VI (virus inactivation) used with Bases (NaOH), for Flushing & pH adjustement
Crossflow and UltraFiltration | DiaFiltration completed with ready-to-use liquid buffers (PBS, NaCl, Tris) for flushing, regeneration and adsorption
Ready-to-Hydrate Powder Buffers combined with Flexsafe® ProMixer match the process requirements:
Pre-weighed powder buffers offer convenience and consistent buffer preparation. Pre-filled powder transfer bags and Flexel® Tank Liners provide dedicated solutions for closed and open mixing. Get started with our off-the-shelf powders or request a customized formulation.
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Buffers are manufactured according to precisely defined specifications:
Liquids are packaged in single-use Flexsafe®️ bags ranging from 250mL to 1000L in ASTM-validated shipping containers.
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Improve handling & reduce footprint
Buffer Concentrated formulations are used at specific downstream steps for a broad variety of applications in the bioprocessing environment. Compared to regular buffers there are several advantages to concentrated buffers:
Water For Injection (WFI)-Quality Water meets or exceeds USP and EP requirements.
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Sartorius offers off-the-shelf NaOH 1M in 20L Flexsafe®️ Bag for a wide variety of applications.
Strong Acids Bases, Alcohols and Detergents are critical in downstream processing:
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Simplify Sourcing and Logistics Thanks to a Comprehensive Offering
The Pro Mixer drive unit levitates and rotates the single-use magnetic impeller in the mixing bag with no surface contact.
The Fast, Flexible and Intelligent Single-Use Mixer for All Mixing Steps in cGMP Bioprocessing
Sartopore® 2 is the industry standard of high-performance polyethersulfone (PES) liquid filters. A broad variety of different pore size combinations ensures highly economic and safe filtration performance. From single-layer high flow solutions to specific Mycoplasma retentive filters, Sartopore®2 perfectly adapts to your specific process needs.
Flexsafe® Pro Mixer technology combines speed and efficiency to deliver high performance mixing during powder dissolution and a levitating impeller to preserve the drug during low shear blending applications. The ergonomic design of the Flexsafe® Pro Mixer 50–3000 L offers ease of handling.
Powder buffers are manufactured according to your specifications to match with process requirements and are packaged in single-use bags, filled up to the exact amount required.
Custom powder buffers will be manufactured to your exact specifications of compositions, molarity, pH and quality
Sartorius powder media and buffers can be prepared and hydrated with WFI-quality water.
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The Flexsafe® Pro Mixer, pre-weighed powder buffers, and powder transfer bags ease buffer preparation for downstream processing.
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Strong acids, bases, alcohols and detergents support chromatography and purification steps in downstream process.
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Buffer solutions can neutralize small amounts of added acid or base, maintaining the solution at a relatively stable pH. This is important for reactions and processes which require specific and stable pH ranges. For example, a change in pH disrupts hydrogen bonds, changing the shape of a protein and impacting the quality of the final product.
Water conductivity is used to measure the purity of bulk purified Water (PW) and Water for Injection (WFI) for the pharmaceutical industry. Conductivity measurements indicate the quantity of dissolved ions present in a water sample and can be used to determine water quality.
Meeting quality standards starts with approved raw materials obtained from qualified vendors.
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Buffer needs and volumes can become very large as processes grow and Sartorius is well-equipped to work with you on minimizing the burden associated with transport logistics by providing an extensive array of ready-to-use downstream processing buffers for protein and viral-based therapeutics.
Sartorius’ production-focused buffer solutions are ideal for clients with known, desired media composition and outcome expectations. Sartorius established a global network of qualified suppliers. Customized packaging, buffers, WFI formats, dangerous goods formats, and release assays are available on request.
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