Single Cell, Clone & Colony Analysis, Screening & Isolation
The CellCelector platform is a fully automated cell imaging and picking system developed for the screening, selection and isolation of single cells, clusters, spheroids and organoids, as well as single cell clones and adherent colonies.
Based on the high scanning and picking speed which results in a fast retrieval of cells, the CellCelector is compatible with single cell RNA analysis applications and perfectly suited for the isolation of living cells. In combination with our Nanowell technology, the CellCelector is the perfect system for high-throughput single cell cloning or single B-cell secretion assays in antibody discovery, as well as the isolation of rare cells (e.g. CTCs) for subsequent analysis.
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Fully automated image-based analysis, screening, sorting and picking of single cells, clones, clusters and adherent cell colonies Learn More About CellCelector Flex
Laminar flow cabinet with efficient control of temperature, humidity and CO2 level for long-term cloning experiments and live cell sorting Learn More About Incubator FlowBox
Parallel screening and isolation of thousands of cells for accelerating antibody discovery and cell line development
Learn More About Nanowell Arrays
Reusable stainless steel and glass capillaries & disposable plastic tips for CellCelector Flex
Learn More About Capillaries and Tips
The CellCelector inverted fluorescence microscope with high resolution optics allows the identification of target cells based on morphological attributes and fluorescence signals. The highly efficient imaging system offers a wide range of image processing options so that even similar cells can be differentiated.
Due to three different picking modules and compatibility with a huge range of standard and custom cell culture labware the CellCelector can be used in a multitude of research areas (e.g. circulating tumor cell/CTC screening, stem cell research as well as cell line development and antibody discovery).
The patented picking technology of the CellCelector is characterized by an extremely gentle cell transfer resulting in high cell integrity and outgrowth rates after picking (including up to 95% and more viability in single cell cloning applications).
The unique combination of a laminar flow cell culture hood and CO2 incubator allows keeping cells in stable environmental conditions during the experiments and provides optimal results and reproducibility.
Equipped with the Single Cell Picking Module, the CellCelector provides gentle aspiration with extremely high precision down to the nanoliter range. Typical application areas are:
Learn More About Single Cell Isolation
Fast generation of clonal pharmaceutical production cell lines with the CellCelector Single Cell Cloning Technology:
Learn More About Cell Line Development
Single cell analysis with the CellCelector allows the detection of rare antibodies with unique properties which are hard to find under conventional screening methods. The system combines selective cell screening, imaging, sensitive single cell secretion assays as well as cell isolation. Hundred-Thousands of cells can be processed in parallel. Individual cells will be screened immediately in specific and multiplexed immunoassays instead of culturing for weeks to reach a minimum number of cells for the assay.
Learn More About Antibody Discovery
The CellCelector, with its specifically designed picking modules for adherent cells and cell colonies as well as for isolation from semi-solid media is extremely gentle, very specific and therefore ideally suited for the clonal passaging of stem cells, stem cell colonies as well as the isolation of specific parts of a stem cell colony. It will support your stem cell research, for example by:
Learn More About Stem Cells
Yes, the CellCelector can isolate both living and fixed cells.
In order to recover cells from a dried surface it should be first pre-wet in PBS (e.g. 24 hours in advance) as cells are recovered using controlled liquid aspiration.
There is no intrinsic dead volume and corresponding cell loss during cell recovery.
The CellCelector can be placed in a biosafety cabinet (yours or a customized one, provided by Sartorius) or in our Incubator FlowBox. The latter does not only provide a sterile environment but also temperature, CO2 and humidity regulation and thus supports the cultivation of sensitive cells.
No. The CellCelector is equipped with a powerful robot arm that can potentially harm users. To protect them, the CellCelector must be installed within housing with a safety lock. At the moment the housing is open, the safety lock cuts immediately the motor's power. All housings offered for the CellCelector are equipped with such a safety lock. For applications which don’t need sterility we offer the CellCelector PCR Hood.
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