Sartobind® Membrane Adsorbers
Sartobind® Membrane Adsorbers – Trusted for More Than Two Decades in Commercial Processing
Sartobind® membranes transform chromatography steps into a highly productive process, from screening to production:
Capsules can be handled like a filter, and cassettes can be installed in less than 10 minutes
From 96-well plates to 5 L capsules and modular cassettes, Sartobind® offers a linear scale-up to all process scales
High flow rates (5 – 20 MV/min) reduce processing time, a dramatic contrast to columns with 0.5 CV/min or slower flow rates
The capsule and cassette formats eliminate the need for column packing, reducing the required facility space
Single-use consumables eliminate need for cleaning validation, while the fit based on capacity vs. flow rate reduces buffer consumption
Sartobind® membranes are available for both flowthrough and bind/elute applications.
Sartobind® Rapid A
Sartobind® Q
Sartobind STIC® PA
Sartobind® S
Sartobind® Phenyl
Ligand
Protein A
Quaternary ammonium
Primary amine
Sulfonic acid
Phenyl
Functionality
Affinity Chromatography
Strong AEX
Salt-tolerant AEX
Strong CEX
Hydrophobic Interaction
Bed height
4 mm
4 and 8 mm for flowthrough and bind/elute
4 mm for flowthrough only
8 mm for flowthrough and bind/elute
Common uses
mAb capture
Endotoxin/DNA/HCP removal
Virus purification
Endotoxin/DNA/HCP/virus removal
HCP/Aggregate removal
Aggregate/HCP/lipid/dye/endotoxin removal
Nucleic acid purification
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Goodbye column packing, hello Sartobind® Rapid A. Meet a unique scalable, highly productive membrane platform for mAb capture.
Sartobind® Rapid A changes the game for mAb capture with a scalable, disposable and highly productive plug-and-play membrane.
Explore Sartobind® Rapid A
Learn how chromatography membranes offer advantages over protein A resins.
See first-hand how Sartobind® Rapid A delivers a tenfold increase in productivity with Sartorius’ new chromatography membrane. Learn more about the product’s scalability, from PD to commercial, and how to remove the mAb capture bottleneck in this webinar.
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Sartobind® IEX membranes enable rapid purification of various biomolecules. Ready-to-use format minimizes set-up time and makes chromatography a simple and highly productive process step.
IEX Type
Strong anion exchange
Salt-tolerant weak anion exchange
Strong cation exchange
Typical DBC at 10% breakthrough
BSA: 29 mg/mL
BSA: 50 mg/mLDNA: 11 mg/mL
Lysozyme: 25 mg/mL
Short term pH stability
1-14
2-12
3-14
Sartobind® Q is highly flexible and used in a wide variety of processes such as the removal of HCP, DNA, viruses, and endotoxins. It is also applied for virus and nucleic acid (DNA/RNA) purification.As with all Sartobind® membranes, the large pore structure is particularly suited to large biomolecules.
The new Sartobind® Q Mini provides 10|20 mL membrane volume, which allows bioprocess customers easier scale-up and is a perfect fit for the production of diagnostic products. Sartobind® Mini is directly scalable with the existing Sartobind® portfolio which ranges from process development (Nano) to commercial manufacturing (Jumbo and cassettes).
Sartobind STIC® PA can operate at high conductivity and can remove DNA at up to 1.5 M NaCl. DNA removal is possible even in the presence of phosphate buffers, which offers some unique processing opportunities.
The new Sartobind STIC® PA Mini provides 10 mL membrane volume, which allows bioprocess customers easier scale-up and is a perfect fit for the production of diagnostic products. Sartobind® Mini is directly scalable with the existing Sartobind® portfolio which ranges from process development (Nano) to commercial manufacturing (Jumbo and cassettes).
Sartobind® S membrane adsorber is approved for use in drug manufacturing to remove host cell proteins at high flow rates. As a cation exchanger, Sartobind® S displays aggregate removal capabilities and typically achieves at least ten-fold higher binding capacity for viruses and virus-like-particles (VLP).
The new Sartobind® S Mini provides 10|20 mL membrane volume, which allows bioprocess customers easier scale-up and is a perfect fit for the production of diagnostic products. Sartobind® Mini is directly scalable with the existing Sartobind® portfolio which ranges from process development (Nano) to commercial manufacturing (Jumbo and cassettes).
Sartobind® Phenyl is a hydrophobic interaction membrane with low ligand substitution. This allows for mild elution conditions for the purification of all biomolecules.
Sartobind® Phenyl membranes can be considered as a replacement to columns for polishing (flow-through) operations and a number of bind-and-elute applications, as they work at much higher flow rates, reduced complexity and without size exclusion effects when purifying large biomolecules.
The typical dynamic binding capacity (DBC) at 10 % breakthrough is:• 9-13 mg/mL mAb• 10 mg/mL BSA• 23 mg/mL Lysozyme
The new Sartobind® Phenyl Mini provides 20 mL membrane volume, which allows bioprocess customers easier scale-up and is a perfect fit for the production of diagnostic products. Sartobind® Mini is directly scalable with the existing Sartobind portfolio which ranges from process development (Nano) to commercial manufacturing (Jumbo and cassettes).
Validate the viral reduction performance of Virosart® HF with our Confidence® Services: Highly purified viruses and expert knowledge.
Are single-use membrane adsorbers a suitable alternative to resins for purifying ADCs? Read our application note to learn more.
The webinar will outline the use of Sartobind® membrane chromatography for the purification of virus-based biologics also linking to the current COVID...
Gain insight into best practices for optimization and sizing of AEX membrane adsorbers for purification processes.
Learn how a batch process for mAb purification can be gradually transformed into an intensified process and then into a connected process.
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