Process Intensification for Chromatography

Increasing diversity of modalities, demands for low product volumes and the push to lower drug prices as well as cost of goods are major factors driving the industry towards process intensification. Advancements and increased adoption of upstream process intensification strategies has led to higher titers making the handling of these titers downstream challenging. Reducing downstream bottlenecks as well as increasing flexibility to switch easily and quickly from one campaign to another are major drivers for chromatography process intensification. Benefits of intensified and continuous chromatography include:

• Increased productivity of the chromatography step(s)
• Reduced footprint (fewer or smaller intermediate tanks)
• Reduced consumable and buffer consumption
• Reduced media costs (especially applicable to expensive affinity resins)