Growth Factors and Cytokines – From Research to Cell Therapy
Growth factors and cytokines are signaling molecules secreted by various cells of the immune system. They have important roles in regulating immune responses and inflammation. Depending on their function and target, they can also affect various cell types. Widely used in the field of cell and gene therapy, growth factors and cytokines are involved in many functions such as cell growth and differentiation, inflammation and coordinating immune responses to pathogens.
Sartorius offers an extensive portfolio of high-quality, recombinant, animal-free and carrier-free growth factors and cytokines - from research use only (RUO) to preclinical and GMP grade - for ex vivo cell culture.
CellGenix® preclinical and GMP growth factors and cytokines are manufactured under the same conditions: equal product quality and performance, enabling a seamless transition from preclinical to GMP.
Explore our quality grades below.
Grade
Product Overview
Intended Use
Quality, Support and Documentation
RUO
High-quality RUO growth factors and cytokines produced using recombinant human DNA technology and are carrier protein-free
For basic research
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Preclinical
Recombinant human growth factors and cytokines: carrier protein-free and cost-efficient alternative to GMP for the early development phase when regulatory support and quality of raw materials have a lower priority.
For preclinical ex vivo use; designed to meet the needs of translational researchers and process developers
Allows for the safe use in accordance with USP Chapter <1043> and Ph. Eur. General Chapter 5.2.12
GMP
Recombinant human growth factors and cytokines: carrier protein-free and manufactured under strict conditions in compliance with relevant GMP and global guidelines to meet the highest quality and safety standard for use in clinical trials and ultimately in patient treatment
For ex vivo use in clinical trials and commercial ATMP manufacturing
Provided with documented evidence of purity, potency, consistency and stability along with expert regulatory and technical support, DMF available for most products Allows for the safe use in accordance with USP <1043>. Ph. Eur. 5.2.12 and in addition ISO 20399:2022
High-quality, recombinant, animal-free and carrier-free growth factors and cytokines - from research use only (RUO) to preclinical and GMP grade
Request a complimentary sample of our high-quality, animal-derived component-free Growth Factors and Cytokines for Research Use Only (RUO).
High-quality RUO growth factors and cytokines produced using recombinant human DNA technology. Carrier protein-free and animal-free.
GMP products are manufactured in compliance with applicable GMP guidelines. Regulatory and technical support services are available.
Immune cells, also known as leukocytes or white blood cells, are involved in protecting the body against infectious disease and foreign invaders. They are produced and derived from multipotent cells in bone marrow known as hematopoietic stem cells.
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Mesenchymal stem cells are multipotent stromal cells that can differentiate into a variety of cell types, including osteoblasts (bone cells), chondrocytes (cartilage cells), myocytes (muscle cells) and adipocytes (fat cells which give rise to marrow adipose tissue). They are characterized by their ability to self-renew, maintain multipotency and differentiate into multiple tissues.
These cells have been widely studied in scientific research for their potential use in regenerative medicine due to their regenerative properties and ability to modulate the immune system. They are being investigated for a wide variety of clinical applications, such as treating diseases and conditions like osteoarthritis, heart disease and autoimmune diseases.
Hematopoietic stem cells give rise to all the other blood cells through the process of hematopoiesis. They are multipotent, meaning they can develop into several different cell types. They are found in the bone marrow of adults, especially in the pelvis, femur and sternum. In cord blood and in the blood stream, smaller numbers of HSCs can also be found.
HSCs give rise to two major lineages of blood cells: myeloid and lymphoid. Myeloid cells include monocytes, macrophages, neutrophils, basophils, eosinophils, erythrocytes and megakaryocytes to platelets. Lymphoid cells include T cells, B cells and natural killer cells.
HSCs are used in the treatment of cancers and other immune system disorders. This is done through bone marrow transplant, peripheral blood stem cells transplant or umbilical cord blood transplant. The goal of these treatments is to restore the blood and immune system to a healthy state.
Induced Pluripotent Stem Cells and Embryonic Stem Cells are both types of pluripotent stem cells, which means they have the ability to differentiate into any cell type in the body.
iPSCs are a type of pluripotent stem cell that can be generated directly from adult cells.
ESCs are pluripotent stem cells derived from the inner cell mass of a blastocyst, an early-stage pre-implantation embryo. Human embryos reach the blastocyst stage 4–5 days post fertilization, at which time they consist of 50–150 cells. They are also known for their ability to propagate indefinitely in culture, maintaining their pluripotency.
Both types of cells are valuable for research and potential therapeutic uses. However, the use of ESCs is controversial because it involves the destruction of an embryo. iPSCs, on the other hand, can be made from adult cells, such as skin or blood cells, avoiding the ethical issues associated with embryonic stem cells.
Organoids are a type of biological model made of organ-specific cells that self-organize into a three-dimensional (3D) miniaturized structure that resembles the corresponding organ. They are derived from stem cells - either ESCs, iPSCs or adult stem cells - which are grown in a culture in the lab.
Organoids can be used to study organ development, disease processes and drug effects. They can mimic the complex structure and function of human organs more accurately than traditional 2D cell cultures, making them valuable tools for studying disease, testing drugs and developing personalized treatments.
Organoids have been created to model a variety of organs, including the brain, kidney, liver, gut, lung and others. However, while organoids can mimic many aspects of organ structure and function, they are still simplified versions of the organs they represent and do not fully replicate all the complexities of an entire organ.
Endothelial cells are a type of cell that line the interior surface of blood vessels and lymphatic vessels, forming an interface between circulating blood or lymph in the lumen and the rest of the vessel wall. They are a thin layer of simple, or single-layered, squamous cells called the endothelium.
Dysfunction of the endothelial cells is a predictor of vascular diseases, including hypertension, coronary artery disease, stroke, insulin resistance, diabetes mellitus, venous thrombosis, chronic kidney failure, tumor growth, metastasis, venous occlusion and severe viral infectious diseases.
Neuronal cells, also known as neurons, are the fundamental units of the brain and nervous system, the cells responsible for receiving sensory input from the external world, for sending motor commands to our muscles and for transforming and relaying electrical signals at every step in between.
Neurons are unique to the nervous system. They have the ability to communicate with each other by sending signals over a long distance. This communication is facilitated by axons, long extensions of the neuron that carry signals to other neurons, and dendrites, shorter extensions that receive signals from other neurons.
There are different types of neurons, including sensory neurons, motor neurons and interneurons. Sensory neurons respond to stimuli such as light, sound, or heat. Motor neurons transmit signals to muscles to cause them to contract. Interneurons connect various neurons within the brain and spinal cord.
Discover more about our range of high-quality, animal-derived component-free RUO Growth Factors & Cytokines
See our proven batch-to-batch consistency across preclinical and GMP cytokines range and ensure clinical and commercial success.
All CellGenix® growth factors and cytokines are animal-derived component-free.
High quality raw materials for cell and gene therapy manufacturing
The main difference between research use only (RUO), preclinical, and GMP areas is in the quality and documentation required for their manufacture and use.
Growth factors and cytokines for RUO are produced for use in basic research and are not intended for diagnostic or therapeutic applications. They are typically manufactured using standard laboratory procedures and may not meet the stringent quality requirements necessary for clinical use. They are often used in academic research or commercial applications such as drug discovery, screening, and target identification.
CellGenix® preclinical growth factors and cytokines are intended for use in the early development phase of cell & gene therapies. They are produced under the same conditions as the CellGenix® GMP growth factors and cytokines, using identical production steps and expression systems. This ensures equal product quality and performance and enables a seamless transition when switching to the GMP grade growth factors and cytokines. Our preclinical grade, therefore, offers a cost-efficient alternative for preclinical phase when regulatory support and quality of raw materials have a lower priority and access to GMP-relevant documentation is not required yet.
CellGenix® GMP growth factors and cytokines are manufactured under strict conditions in compliance with relevant GMP and global guidelines to meet the highest quality and safety standard for use in clinical trials and ultimately in patient treatment. The difference to CellGenix® preclinical is that we offer regulatory support, and more comprehensive QC testing including tighter specifications and documentation.
Growth factors are signaling molecules that regulate cell proliferation, differentiation, and migration. "Cytokine" was first used to define a subset of growth factors influencing immune and hemopoietic cells. However, it is now clear that cytokines can act on many different cell types and have diverse effects on proliferation and differentiation. Therefore, "cytokine" is now used more broadly and interchangeably with "growth factor."
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