Hollow Fiber TFF Modules
Gentle and Fast Separation. Increase Recoveries. Decrease Risk.
In certain biopharmaceutical production processes, the TFF step has special requirements leading to low recovery, including clogging, excessive stress, shear sensitivity of the target molecule, or high viscosity.
Sartorius Hollow Fiber TFF modules can help improve recovery by being able to process shear-sensitive molecules gently during separation and at the same time handle high biomass and high cell densities.
Hollow Fiber TFF incorporate a robust, fully inhouse produced membrane. Since it's ready-to-use, it eliminates the need of pre-flushing which saves time and cost.
Watch this video to find out more about the time and cost benefits that Sartorius' singe-use Hollow Fiber filters can offer and how they can help to improve your processes.
Consult Our Experts
The macro-void-free hollow fiber membrane and open channel flow path reduce shear stresses and enable efficient separation.
Glycerin free membrane, no expensive WFI for pre-flushing required.
A range of pore sizes and molecular weight cutoffs support diverse needs. Conditions established at pilot-scale apply to process-scale. Customized assemblies are available with our Single-use Line.
In certain biopharmaceutical production processes, Tangential Flow Filtration (TFF) step has special requirements (due to clogging, shear sensitivity or high biomass or viscosity) leading to low recovery and yield. Sartorius Hollow Fiber TFF modules can help improve recovery by being able to process:
Explore the System
Sartorius Hollow Fiber TFF modules are made of mPES and available in different sizes, surface area and module diameters to provide linear scale-up from laboratory to manufacturing scale. They are the ideal solution to save money, time, and space. Compared to reusable setups, single-use TFF can save up to 50% of facility time by eliminating rinsing, integrity testing, normalized water permeability (NWP) testing, cleaning, consumable removal, and storage operations.
Single-use Line
Steamer Line
Re-use Line
Applications
Single-use applications
Aseptic applications
Multi-use applications
Autoclavable
No
Yes
Available in Assembly
Batch Volumes
10 mL up to 1500 L
10 mL up to 250 L
Pore Sizes &Membrane Cut-offs
0.1 µm, 0.2 µm, 0.45 µm;3 kD, 5 kD, 10 kD, 30 kD, 50 kD, 100 kD, 300 kD, 500 kD, 750 kD
Fiber ID
0.5 mm, 1.0 mm
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The Single-use Line offers a true ready-to-use TFF module. These modules are:
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The Re-use Line modules can be easily cleaned after each use and stored.
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The Steamer Line modules are autoclavable. The modules are delivered gamma-irradiated and ready-to-use.
Explore Steamer Line
CrossflowExpert™ calculators simplify hollow fiber module selection and operation conditions needed to perform crossflow filtration application. Enter your data and the calculator will solve for the application.
Configure Your Solution
Our Single-use Line products allow you to design complete assemblies that provide all components needed for a fully integrated TFF solution. A customized Flow Assembly combines the Single-use Line Hollow Fiber TFF module of your choice with single-use pump heads; feed, retentate and permeate tubing; single-use pressure sensors; transducers; flow sensors and meters; and aseptic connectors, plugs or bags.
Consult with Sartorius experts to design a fully customized separation system incorporating our hollow fiber (hollow fibre, HF) TFF modules. Or build your own solution using our full portfolio of products and purpose-built accessories, which include monitoring and control systems, connector kits, and stands and holders.
Take advantage of vertical lab and production space with stainless steel Flow Stands and Flow Stand holders to secure your hollow fiber TFF modules. The Flow Stands come with easy-to-use handles to quickly adjust the height of your module or assembly.
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Flow Connector Kits are designed specifically to connect hollow fiber TFF modules to Flow Assemblies. The kits can include the following, as needed:
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