The Sartorius Resolute® multi-use chromatography systems are configurable automated systems with proven scalability, accompanied by extensive support pre and post-sales. Resolute® multi-use systems offer robust configurable stainless-steel-based solutions. High precision industry-standard sensors allow for wide operational flow rates and in-line dilution options.
Attributes
Resolute® Flowdrive ATEX
Scale of operation
Pilot, Clinical and Commercial manufacturing
Pilot, clinical and commercial manufacturing
Automation
Common chromatography software
Footprint
≥990x1300mm
Application
Isocratic and gradient batch chromatography
Isocratic and gradient batch chromatography in explosive environments
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Resolute® Flowdrive MU provides an established portfolio of standard and customized products from clinical development to commercial manufacturing. The systems cover a full range of applications with the highest standards in design and operation. Besides isocratic separations, they can run precision gradients and perform in-line dilution. Resolute® Flowdrive MU systems are capable to process both columns and membrane chromatography.
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Industry standard instrumentation
High quality manufacturing standards
Operator focused software and imbedded specific analytical tool are optimized for clinical and commercial manufacturing to GMP
Process focused engineering design to meet customer needs (backed up by rigorous project management from process engineers)
We provide process solutions with both standardized and fully customized products, and offer comprehensive local support wherever the location.
Full documentation package to ensure GMP standards
Availability to demonstrate systems at our facilities
Dedicated chromatography support through our process specialists
Pre-sale consulting from experiences engineers
Major components designed for conformance to BPE for inherent sanitary design
Validation and compatibility with pharmaceutical manufacturing requirements
Pump head design gives virtually pulsation-free flow
Comprehensive support documentation in accordance with GAMP guidelines
Easy maintenance and replacement
Consistent scale-up
6 barg (87 psig)
Yes
System
2– 150
20 – 500
Piping id
4.6 mm (0.18 in.)
15.7 mm (0.62 in.)
Pipe Connections
12.5 mm (0.5 in.)Sanitary Clamp
Dimensions
Uncrated Weight
250 kg (550 lbs)
275 kg (606 lbs)
300 kg (660 lbs)
Description
Specification
Pumps
Two x Four -piston diaphragm pump
Gradient/In-line dilution capability
5 to 95 % typical (see diagram)
Inlets including product sample
8
Outlets including waste
4
Column flow control
Forward, reverse, by-pass
Bubble trap
Automated vent control, with by-pass
Filter
Pre-column, 0.2 µm Pall standard, with by-pass
Air sensor
Sample feed, pre-column
Item
Position
Range
Accuracy
Flow meter
Post-column
0 - 1,500 L/H
± 1 % (of reading)
Pressure transmitter
Pre and post-column
0 - 6 bar (0 - 87 psi)
± 0.5 %
Conductivity
0 - 200 mS
± 2 %
Temperature
Pre-column with post-column option
0 - 100 °C
pH
0 - 14 pH
± 1 %
UV
0 - 5 AU, 280 nm
± 2 % (± 1% typical)
Pipework
Stainless steel 316L
Stainless steel 316L, EPDM, Santoprene, Polypropylene
Valves
Stainless Steel, EPDM
Acrylic, Stainless steel 316L, EPDM
Polyethersulfone, PVDF or as specified
Instrumentation
Stainless steel 316L, Titanium, EPDM, PVDF, Quartz, Glass
Elastomeric seals
EPDM or silicone
The Resolute Flowdrive Atex product family provides a solution for customers requiring systems for use in an Explosive environment. Rated to ATEX Zone or Class 1 Div 2 these systems are fully configurable and come in a range of sizes to suit a wide range of clinical and commercial applications.
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