Tangential Flow Filtration Cassettes
Efficient filtration is a critical step in biopharmaceutical processing. Sartorius tangential flow filtration (TFF) cassettes provide high-performance separation in various upstream and downstream bioprocessing unit operations. They are available in a range of molecular weight cut-offs and micron range, from lab scale to process scale, in single-use and re-usable formats. When used together with associated TFF systems and filter holders, these TFF cassettes provide a complete seamless solution for efficient, robust, and reproducible TFF operations, including ultra- and microfiltration.
IVT reactions are efficient for mRNA production, and new analytical tools can help you achieve high recovery and quality.
For the retention of materials in the ultra-scale range (e.g., proteins, mAbs, or viral particles)
Attribute
Hydrosart®
Polyethersulfone (PES)
Nominal Molecular Weight Cut-offs
2, 5, 10, 30, 100, 300 kDa
1, 5, 8, 10, 30, 50, 100, 300 kDa
Filtration Areas
10 cm², 50 cm², 200 cm², 0.1 m², 0.4 m², 0.6 m², 0.7 m², 1.4 m², 3.0 m², 3.5 m², 7 m², 14 m²
10 cm², 50 cm², 200 cm², 0.1 m², 0.4 m², 0.6 m², 0.7 m², 1.4 m², 3.0 m², 3.5 m²
Typical Process Fit
Peptide, Oligonucleotide, Proteins (Albumin), Blood Factors, Monoclonal antibodies (mAb), Vaccines, Cell & Gene Therapy, pDNA, mRNA, ADC, recombinant proteins, Viral vectors
Proteins (Albumin), Blood Factors, Monoclonal antibodies (mAb), Vaccines, Cell & Gene Therapy, pDNA, mRNA, ADC, recombinant proteins, Viral vectors
Self-contained
Available
Partially Available
For the retention of material on the micro-scale range (e.g., cells and visible particles)
Pore Size
0.2 & 0.45 µm
0.1 µm
Membrane Areas
200 cm², 0.1 m², 0.4 m², 0.6 m², 3.0 m²
200 cm², 0.1 m², 0.6 m², 3.0 m²
Cells, Particles
Cells, Particles, Mycoplasma reduction
Hydrosart® high-performance membrane is a stabilized cellulose-based membrane that has been optimized for biopharmaceutical process applications.
The polyethersulfone (PES) membrane is well-established in the biotechnological and pharmaceutical industries.
Sartocon® and Sartocube® Microfiltration cassettes are available with effective filtration areas from 0.02 m² up to 3.0 m². Available pore sizes are 0.45 µm and 0.2 µm with Hydrosart® membrane as well as 0.1 µm with polyethersulfone membrane .
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Sartocon® and Sartocube® Ultrafiltration cassettes are available with Hydrosart® and polyethersulfone membrane with effective filtration areas from 50 cm² up to 3.5 m². Available cutoffs range from 1 kDa up to 300 kDa.
Sartocon®️ and Sartocube®️ Self Contained Units (SCUs) are 0.14 m² to 14 m² pre-sterilized disposable units suitable for cGMP environments. The SCU is available in a variety of molecular weight cut-offs and in Hydrosart®️ and polyethersulfone (PES) membrane types.
Single-pass TFF simplifies ultra- and diafiltration by simultaneously concentrating and diafiltration in one pass instead of multiple recirculations.The Sartocon® SP cassette is a self-contained closed processing device that is delivered irradiated to minimize biocontamination risk.
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High-performance separation in various upstream and downstream bioprocessing unit operations.
CIP flushing cassettes are ideal for sanitizing many filter holders. On-the-spot cleaning saves process and validation time.
IVT reactions can now produce mRNA reaching 12g/L, and our data show Hydrosart TFF cassette and Sartopore 2 offer high recovery and quality.
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