Tangential Flow Filtration Systems
Sartorius offers flexible tangential flow filtration (TFF) systems for process development and clinical trials, from laboratory environments up to commercial production batches. The TFF portfolio can flex to accommodate individual requirements, with a range of options that includes cost-efficient multi-use systems or closed systems with single-use flow kits for aseptic processing.
A range of TFF systems and components are available, offering flexibility and performance, from process development to commercial-scale in GMP environments.
Attributes
Ambr® Crossflow
Sartoflow® Smart
Sartoflow® Advanced
Sartoflow® 150
Membrane Area
10, 50 cm²
50 cm² - 0.14 m²
0.1 – 0.21 m²
0.1 – 0.4 m²
Vessel Volume
100 mL
1 L with mixing
10 L
5, 10, 20 L
Flow Rate / Pump Capacity
0 – 80 mL/min
1 – 100 L/h
700 L/h
5 – 150 L/h
Minimum Recirculation Volume
5 mL
< 20 mL
~ 170 mL
~ 130 mL
Automation Level
Fully
Semi
Process Mode (multi/single)
Multi-use or single-use
Multi-use
Single-use
Learn More
Sartoflow® Expert SU
Sartoflow® 1000
Sartoflow® 4500
Flat sheet: 0.1 – 0.4, 1.4 m²
20 L mixing
10, 20, 100 L
900 L/h
20 – 900 L/h
100 – 4500 L/h
~ 600 mL
~ 1.2 L
Depends on bag size
Ambr® Crossflow provides molecule behavior data in early development on viscosity, buffer composition, shear stress and performance in membrane processes. It also contributes important additional decision criteria to help guide and accelerate the candidate selection process.
Ambr® Crossflow allows developers to study factors relevant to manufacturability, providing the capacity for up to 16 automated, parallel trials. The system is capable of processing volumes as low as 5 mL recirculation volume.
The Sartoflow® Smart is a modular and flexible small-scale benchtop TFF system for ultrafiltration and diafiltration. It is designed for laboratory environments and suitable for process development, clinical trials and small batch cGMP production. Sartoflow® Smart is used in many downstream processes, such as purification of vaccines, monoclonal antibodies and recombinant proteins.
The Sartoflow® Advanced is a modular benchtop TFF system with a variety of options for ultrafiltration and diafiltration.
The Sartoflow® 150 is an automated single-use tangential flow filtration system (SUTFF). Its compact footprint and low recirculation volume are optimized for small-scale process ultrafiltration and diafiltration (UF/DF) applications of 2–20 L batch volumes.
SPTFF simplifies ultrafiltration and diafiltration with an inflow process mode. It helps mAb manufacturers shorten setup and enhance efficiency.
Sartoflow® Expert SU is a fully automated TFF system with a closed single-use loop for PD up to pilot. In addition to state-of-the-art TFF, it can be configured to streamline 3 unit operations for 1-20 L ADC synthesis on one system, thus increasing safety and quality.
The Sartoflow® 1000 facilitates automated processing of monoclonal antibodies, recombinant proteins and vaccines in batch volumes from 20 to 200 L.
An intuitive interface design simplifies automation of TFF process sequences, with complete single-use flow kits that incorporate all critical sensor and instrumentation technologies.
The Sartoflow® 4500 single-use tangential flow filtration (SUTFF) system has a user-friendly control interface for operating fully automated ultrafiltration and diafiltration (UF/DF) applications for batch volumes of 200 to 2000 L (1 to 15 kg). The Sartoflow® 4500 is compact, has low hold-up volume, and the capacity to run cassette surface areas up to 10 m².
Hydrosart® TFF cassettes let you focus less on cleaning and sterilizing due to exclusive membrane tech with high chemical resistance and long product...
See how Sartorius services help support maintenance and longevity of your Research & Biomanufacturing Equipment while ensuring minimal downtime.
Please select your country so we can show you products that are available for you.
The content of our website is always available in English and partly in other languages. Choose your preferred language and we will show you the content in that language, if available.
Shop Sartorius Products Now