Webinar Series - The mRNA Webinar Collection | Sartorius

The mRNA Webinar Collection

mRNA Expertise Within Reach

Under the pressure of delivering billions of vaccine doses during a pandemic, manufacturers focused heavily on the safety and efficacy of vaccines. This unprecedented demand for mRNA production revealed a temporary challenge — capacity and technology bottlenecks. Future mRNA development will benefit from optimized production and purification processes to alleviate these challenges.

Sartorius scientists started developing new chromatography solutions for mRNA therapies before the pandemic. In these webinars, our experts share real-world case studies that demonstrate the flexibility of monolithic chromatography when implemented into next-generation mRNA processes.


What You Will Learn

  • Learn how to break down bottlenecks with a monolithic chromatography toolbox that offers purification solutions across multiple mRNA production platforms
  • Review the real-world challenges our customers faced in their mRNA manufacturing efforts and how Sartorius partnered with them to develop innovative solutions
  • Underscore the importance of flexibility in mRNA purification and highlight some options from the Sartorius mRNA purification toolbox

Start Exploring our Webinar Collection Now

Webinar Series: Your mRNA Process, Simplified

icon-webcast

Part – 1: Increase pDNA Purity and Yields

In part one you will learn how to achieve higher yields in the plasmid DNA by ensuring the quality and purity of the raw materials and taking other steps to optimize the production process.


What Will You Learn

  • Review strategies to minimize introduction of product-related contaminants in the IVT reaction
  • Explore ready-to-use solutions for scalable chromatographic purification of plasmid DNA
  • See real-world impact of the HiP2 Plasmid Process Pack for purification of linearized pDNA

Watch Webinar

icon-webcast

Part - 2: Break Down the mRNA Bottleneck with Rapid Analytical Strategies

In part two of the 'Your mRNA process, Simplified' webinar series, we continue to explore how improved processes, analytics, and tools can help meet the unprecedented demand for mRNA.


What You Will Learn

  • Discover how analytical HPLC with CIMac columns can improve in-process control and quality control of the mRNA production process
  • Understand the value of rapid analytics during process optimization, for process monitoring and final quality control
  • Review the real-world results of analytical strategies implemented in mRNA production

Watch Webinar

icon-webcast

Part - 3: Select the Right Purification Approach for Your Process

In this final webinar of the series, Sartorius purification experts demonstrate the flexibility that can be achieved with an mRNA purification toolbox featuring monolithic chromatography.


What You Will Learn

  • Discover a scalable purification solution for commercial manufacturing of mRNA therapeutics
  • Become familiar with monolithic chromatography solutions designed to overcome challenges in mRNA purification
  • Learn how to implement affinity and non-affinity capture of mRNA from an IVT reaction mixture using CIMmultus® monoliths

Watch Webinar

Preparing for the Emergence of mRNA Therapeutics
icon-webcast

How to Evolve mRNA Production and Purification in the Aftermath of COVID-19 Vaccine Development

This webinar features an exclusive panel discussion where our mRNA experts discuss current approaches and bottlenecks of mRNA production and lay out their vision for truly optimized next-generation processes.


What You Will Learn

  • Review the real-world challenges our customers faced in their mRNA manufacturing efforts and how Sartorius partnered with them to develop innovative solutions
  • Underscore the importance of flexibility in mRNA purification and highlight some options from the Sartorius mRNA purification toolbox, such as the Oligo dT affinity monolith and PrimaS non-affinity monolith columns for the capture of mRNA
  • Present a method for rapid analytical monitoring of IVT reactions with CIMac® PrimaS

Watch Webinar

icon-webcast

Integrated Production Process of mRNA from E. coli to Highly Purified mRNA

In this video Aleš Štrancar, Managing Director – BIA Separations, a Sartorius company, discusses how a new purification approach from E. Coli through mRNA production leads to improved recoveries, extra-low protein impurities, and efficient dsRNA removal.


What You Will Learn

  • Explore a new purification approach starting from E.coli through to mRNA production, resulting in improved recoveries, extra-low protein impurities, and very efficient dsRNA removal
  • See the potential impact of implementing rapid analytics of the IVT reaction, including optimized conditions and improved transcription numbers
  • Learn how optimized conditions for pDNA linearization minimize protein contamination, facilitate purification, and may prevent aggregate formation

Watch Webinar

Consult Our Experts