Exploring The Progress and Promise of iPSCs in Disease Modeling
Last updated: April 2024
Neurodegenerative diseases, such as Alzheimer's and Parkinson's, cause progressive neuron damage leading to loss of motor skills, memory, and cognition, significantly impacting patients and healthcare. Current treatments offer only symptomatic relief without halting disease progression. Research is hindered by the blood-brain barrier, which limits drug delivery, and by inadequate models like post-mortem cultures, immortalized cell lines, and animal models that fail to accurately mimic human diseases.
Advanced cell models like iPSCs and 3D cultures show promise in addressing these challenges. iPSCs allow for personalized disease modeling and drug testing, while 3D cultures replicate the brain's structure, facilitating complex disease studies and scalable drug testing. These models also reduce ethical concerns compared to embryonic stem cells.
Along with the promise of iPSCs in disease modeling comes many challenges, such as standardizing iPSC protocols and validating their clinical relevance. Download this eBook to learn about best practices for leveraging iPSCs in disease modeling, tips for streamlining workflows, as well as industry-leading solutions that optimize R&D for advanced cell models.
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Figure 1. Cover of eBook
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