Immunotherapy harnesses the immune system to fight cancer and has changed the way we treat many types of cancer. Engineered immune cells, including chimeric antigen receptor (CAR) T and CAR natural killer (NK) cells, represent a powerful immunotherapeutic approach. CAR T or NK cells are engineered to target a specific tumor antigen by expressing a synthetic chimeric receptor with both antigen-binding and T or NK cell-activating function.
As our understanding of the anti-tumor immune response grows, a number of strategies have emerged for engineering immune cells for cancer therapy. Stem cell-derived NK cells create the possibility for “off-the-shelf” CAR NK cells, and approaches to improve the tumor selectivity of CAR T cells reduce their toxicity. This opens the door for the expanded use of CAR T and CAR NK cells and combination with other therapies.
The reviews and research in this Cell Press supplement offer a snapshot of the latest advances in this rapidly evolving field.
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