An Advanced Flow Cytometry Solution for Screening an Immunomodulatory-Based Sar Compound Library

The efficient execution of large drug screens requires innovation in instrumentation and data analysis to more rapidly identify potential drug candidates. This talk highlights the use of advanced flow cytometry to perform a structure-activity relationship (SAR) compound library screen on PBMCs, which enabled:

• Measuring multiple parameters such as cell viability, immunophenotyping and cytokine secretion in a miniaturized assay format.
• Rapid identification of compounds that promote cytokine and T cell activation using novel multiparametric data analysis and visualization tools

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