Equipment-Free Chromatography: Using Sartobind® Lab Units with a Syringe Protocol

Equipment-Free Macromolecule Purification: Using Sartobind® Lab Units with a Syringe

 Last updated: February 2023

Overview

This protocol describes how to operate Sartobind® Lab units manually, with a syringe. Unlike resin-based columns, the macroporous structure of Sartobind® membrane adsorbers enables rapid transport of macromolecules to the functionalized surface by convective flow. This supports reliable, equipment-free purifications by syringe at much faster flow rates and shorter residence times, without exceeding pressure limits or compromising target molecule yields.


  • Document type: Protocol
  • Page count: 3
  • Read time: 3 minutes


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Key Takeaways

In this protocol, you will find:

  • A list of required materials
  • General guidelines for handling Sartobind® Lab units with a syringe
  • Visual overview of the capture-wash-elute process
  • Step-by-step written instructions
  • Hints to speed up your process

This Resource is Designed for:

  • Lab researchers
  • PhD students
  • Research technicians
  • Research associates
  • Process development scientists

Applications Supported:

  • Purification
  • Ion exchange chromatography
  • Affinity chromatography
  • Capture purification
  • Protein purification
  • Virus purification
  • Nucleic acid purification
  • Crystallography
  • Structure-function studies

Figure 1. Visual step-by-step instructions for syringe-driven purifications

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