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Reliable, Consistent and Traceable Preparation of Buffers and Solutions for Antibody Analysis
Last updated: October 2020
Antibodies are subject to various issues due to chemical and physical instabilities. These effects may change the pharmacokinetics of antibodies (e.g. due to loss of antigen binding activity, impaired resorption or degradation by proteases). Because of these potential instabilities, pharmacopeias dictate produced antibodies must be thoroughly tested before they can be applied for treatment of patients.
US Pharmacopeia Chapter 129 lists several analysis methods for therapeutic antibodies, including size-exclusion chromatography (SEC) and liquid chromatography (LC) with fluorescence detection. Each of these methods require the preparation of buffers and solutions, many of which require the precise weighing of multiple components.
Download this application highlight to learn about the relationship between therapeutic antibodies and analytical balances and how Cubis® II can streamline the testing process.
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