Innovations for Protein Therapeutics Discovery & Development
Therapeutic proteins have proven to be useful tools not only in cancer immunotherapies but also as promising treatment options for infectious diseases like COVID-19. Among some already licensed monoclonal antibodies (mAbs), several new developments (or molecule types) like next generation antibodies (bispecific, nanobodies, antibody fragments and antibody drug conjugates (ADCs) are in pre- clinical and clinical trials to investigate whether they can effectively treat different types of cancers and other diseases.
To mount a successful mAb, nanobody, bispecific antibody or antibody fragment discovery and development program to address difficult target classes, you need the latest technologies that allow rapid identification and characterization of candidate molecules to identify those with superior target reactivity and to further optimize their functionality.
Our innovative solutions for discovery and development of protein therapies streamline the workflow and increase productivity.Accelerate your biotherapeutic development and still have peace of mind.
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Fully automated cell imaging and picking system developed for screening, selection and isolation of single cells, clusters, spheroids, and organoids as well as single cell clones and adherent colonies.
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Enables real-time, live-cell imaging and analysis directly inside your incubator. Measure kinetic effects of your antibody treatment on target cells without ever having to remove cells from the incubator.
High-throughput, suspension cell and bead analysis platform for rapidly profiling of cell phenotype and function in therapeutic antibody discovery workflows. Ideal for those screens where cells are precious or limited in number, the iQue® 3 is the fastest way to generate high-content data from small samples.
Octet® systems are used for affinity ranking, epitope binning of small to large antibody matrices, Fc-receptor binding, cross-reactivity testing of other species, glycosylation screening, characterization of antibody-antigen binding kinetics and affinity, bispecific testing, and titer analysis for protein expression, all in one high throughput, easy-to-use system.
With exceptional sensitivity for both small and large molecules, the Octet® SF3 allows users to generate high-quality kinetics and affinity data in a fraction of the time compared to standard multi-cycle kinetics.
Sartorius’s mAb purification mini platform is ideal for small-scale purification of your mAb from up to 1 L of cell culture supernatant.
The mini platform includes up to seven steps to take you through all the workflows necessary for mAb purification: cell clarification and filtration, antibody capture by affinity chromatography, purification step(s), concentration, and sterile filtration.
Each of our application steps maximizes output for the next step in the workflow, to support a seamless mAb purification process with maximum output.
Lab-dedicated, plug and play Vivaflow® cassettes enable an effortless, cost-effective transition from centrifugal to crossflow ultrafiltration. The unique flip-flow path and modular design provide high speed concentration of larger sample volumes, while a broad choice of membrane materials and MWCOs ensure the highest target recoveries. All of this, with the simple turn of a dial on a standard peristaltic pump.
Sartobind® Lab Protein A affinity membrane adsorbers are ideal for rapid purification of antibodies, include IgGs and mAbs. The large pore size allows 10-fold faster flow rates than conventional resin-based columns, and cycle times of only 10 minutes. In the FPLC-compatible syringe filter format, affinity purification can be performed as simply as filtration.
Sartorius is proud to offer a truly stunning portfolio of filtration devices all designed to maximize filtration efficiency, yet also be a cost effective and easy filtration solution for the researcher and laboratory as well.
Vivapure® and Sartobind® Lab ion exchange devices utilize the popular, process-ready Sartobind® membrane adsorbers with Q or D ligands for rapid, easy target purification and contaminant removal by anion exchange. The choice of spin column or syringe filter formats offers the ultimate in flexibility and convenience, from parallel purification by centrifuge, to larger-scale separations with a syringe, pump or FPLC system.
Vivapure® and Sartobind® Lab ion exchange devices utilize the popular, process-ready Sartobind® membrane adsorbers with S ligand for rapid, easy target purification and contaminant removal by cation exchange. The choice of spin column or syringe filter formats offers the ultimate in flexibility and convenience, from parallel purification by centrifuge, to larger-scale separations with a syringe, pump or FPLC system
The comprehensive range of Vivaspin® devices caters to virtually any ultrafiltration | diafiltration application for initial sample volumes from 0.1 to 100 mL. The risk of sample loss through concentration to dryness is eliminated by design, while maximum process speeds and target recoveries are achieved through high-area membranes available in multiple materials and MWCOs. Furthermore, retentate retrieval is simplified from the unique angular dead stop pockets of Vivaspin® Turbo
Sartoclear Dynamics® Lab is a new, one-step method for harvesting mammalian cell cultures with high cell densities. Consistent results, ease of use and exceptional speed are the key characteristics of this technology.
Cell line development with intelligent tools, services, and solutions for your unique needs.
Accelerate drug development by using Design of Experiment (DOE) to efficiently plan your experiments and analyze your results with MODDE®.
Identification and selection of optimal clones that secrete high levels of the desired antibody is one of the critical and time-consuming steps in the antibody discovery process.
Explore next-generation therapies such as ADCs and bsAbs for oncology
Discover the latest antibody screening tools, how to access novel mAbs, improve the identification and qualification of hits during screening, and acc...
Fully automated, image-based screening and isolation of clones and single cells for antibody discovery.
Ensure confidence in your mAb discovery and development program with solutions from Sartorius.
Neutralizing antibodies will play a critical role in future vaccine and therapeutics development and have become a major focus for researchers.
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