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Upstream Solutions for Cell and Gene Therapies
Polyplus is a leading upstream solutions provider for advanced biologic and cell and gene therapy production from research to commercial scale.
An innovator in nucleic acid delivery, the legacy portfolio features process-centric transfection reagents, kits, and support services for viral and non-viral delivery. Custom plasmid vector design and plasmid and protein manufacturing were integrated into the offer in 2022 to expand the products and services portfolio to help the industry optimize process economics while meeting strict scientific and regulatory standards.
Superior AAV titers in suspension cells Improves process economics Designed for Industrial scalability Available at GMP grade
Gold standard PEI-based transfection reagent for scalable virus production Highly Reproducible and reliable Available at GMP grade
Safe, efficient and secure Modulate LNP properties to adapt the mRNA biodistibution In vitro and in vivo proof of concept available
Ensure successful cloning through our innovative assembly technology, our powerful algorithm, our online design tool, and our dedicated plasmid engine...
Unique scalable proprietary process allowing High purity plasmid production very low endotoxin level in Research, HQ & GMP grades with tight timel...
Find more FAQs on cell & gene therapy here.
Our transfection reagents are manufactured in compliance with the ICH Q7 GMP part II guideline that ensure a validated and aseptic manufacturing process.
For lentivirus production, we recommend FectoVIR®-LV as it is currently the best product for this application, both in adherent and suspension cell culture systems.
PEIpro® and FectoVIR®-AAV are different both in terms of molecular structure and formulation. FectoVIR-AAV is especially well suited for AAV production in suspension cells.
Our unique and scalable proprietary process allows plasmid production from 50mg to 20g in Research, HQ & GMP grades.
Within the LNP formulation, our Cationic lipids can modulate physicochemical properties and impact subsequent potency and biodistribution of formulated LNPs while improving mRNA stability.
Novel engineered pHelper plasmid to improve yield and quality of several AAV serotypes in suspension cell culture systems.
Next-generation transfection reagent for large scale AAV manufacturing.
In recent years, Sartorius has been continuously making acquisitions, expanding its portfolio by new, complementary technologies.
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