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From Contamination to Clarity: The Essential Role of Ultrapure Water for LCMS
Author: Tiffany Yesavage, Ph.D., Published by BioCompare
Liquid chromatography-mass spectrometry (LCMS) is a common analytical technique that combines high-resolution chromatographic separation with mass spectrometry for identification and quantification of various substances. LCMS requires ultrapure water not only for the mobile phase, but also for sample dilution, standards, blanks, sample preparation, rinsing, and instrument cleaning.
There are common contaminants that affect LCMS performance, such as organic compounds, bacteria, particulate matter, dissolved atmospheric gases, and inorganic ions. These contaminants can cause a variety of problems, including peak overlap, baseline instability, high background noise, ghost peaks, potential column damage, and lack of reproducible results.
Download the article to learn more about ultrapure water for LCMS and how ultrapure water systems can reduce contamination.
Read time: 8 minutesLast updated: November 2023
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