Process Optimization Strategies For Virus Filtration of Human Plasma Products
Learn how different types of adsorptive pre-filters reduce the binding of highly fouling species, determining the throughput of the final virus filter as well as the overall process economics of the virus filtration step for plasma-derived proteins. In addition, other possible strategies to counteract fouling of the final virus filter are discussed such as dilution of the feed stream.
Key Learning Objectives:
- Fouling mechanisms and their relation to throughput for virus filters from different matrices
- Process optimization strategies to increase the robustness of filter fouling
- Proof that critical process parameters do not affect viral retention for surface-modified PESU virus filters
- Validation strategies and best practices for integrity testing of virus filters and adsorptive pre-filters