Research the Industry Standard for Label-Free of Biomolecular Interactions Analysis (BIA) - The Octet® BLI platform enables label-free biomolecular interaction analysis based on Bio-Layer Interferometry (BLI) technology. Download the latest application notes, infographics, eBooks, and more to support your label-free research and development.
Boost your research and commercialization goals by combining BLI and SPR at an attractive promotional price.
Anti-drug antibodies (ADA) can modify the drug’s pharmacodynamics (PD) and/or pharmacokinetics (PK), making it crucial to detect them through an immun...
A comprehensive guide for designing and performing assays that accurately measure the binding kinetics of biomolecular interactions and analyte concen...
Faster time-to results allows assessment of accurate and precise data earlier in the workflow
Introducing label-free platforms, the technology, capabilities, and advantages of label-free binding assessment
Current regulatory guidelines for assay validation were harmonized for kinetic-based assay to derive a common set of parameters.
Octet® BLI to measure and characterize CRISPR/Cas mediated binding and Gene activation
With Octet® BLI Workflows
Accelerating Antibody Discovery by Monitoring Titer and Glycosylation With the Octet® Platform
Nanoparticle (NP) vaccine and antigen delivery platforms have emerged as a promising approach due to their ability to interact with immune components
Expanding Octet® Applications in Downstream Biologics Characterization
Without Added Sample Purification Steps
BLI Technology Plays a Vital Role in the Race for a SARS-CoV-2 Treatment
Researchers are using the Octet® system to understand the virus's binding mechanisms as a first step in the development of a vaccine
Quality control of biological products to support clinical trials and post market assay activities require the evaluation of multiple critical product...
For Accurate Determination of Kinetics and Affinity Rate Constants
Octet® GxP packages support the GMP compliant implementation, including 21 CFR Part 11 software, validation packages, and biosensor validation support...
By Octet® Bio-Layer Interferometry (BLI) Platforms
Using Octet® BLI Technology
With Label-Free Biosensor Technology
A fundamental understanding of the differences between affinity and avidity is essential when designing and developing assays
Learn how we report the development of a rapid, high-throughput capsid assay for AV quantification on the Octet® BLI platform that demonstrates excell...
Biophysical Characterization of the Binding of SARS-CoV-2 to the ACE2 Protein Using the Octet® R4 Bio-Layer Interferometry Platform
The cell line development group at Biogen IDEC needed a robust assay for the measurement of Fc-fusion protein in crude cell culture supernatants.
For Rapid and Direct Quantitation of AAV Capsids
Scientists from Elanco® use Octet® BLI to rapidly design and establish a preclinical PK method for analyzing canine antibodies
Using Octet® SAX Biosensors
Assay design recommendations and best practices for producing the highest quality of kinetic data.
Epitope binning through cross competition assays is a powerful tool in evaluating functional diversity in antibody clones.
Whether you're assessing FcRn-Antibody or FcγR-IgG binding interactions, you need a high throughput, versatile, and easy to use solution.
For Affinity Characterization of Human IgG-Antigen Interactions and Quantitation of Human IgGs or Human Fc Region Containing Proteins
A novel approach for relative mannose content screening and ranking of human monoclonal antibody (mAb) samples using the Octet® GlyM Kit
For Process Development and Quality Control
Rapid, accurate and cost-effective quantitation of monoclonal antibodies (MAbs) is essential for bioprocessing.
A method for evaluating the binding of an Fc gamma receptor III (FcγR) molecule to the widely characterized NIST mAb.
Rapid quantitative screening of bispecific antibodies using Protein A and HIS1K biosensors
This application note describes the power of using the Octet® platform along with Ambr® 15 Cell Culture to identify optimum yield conditions.
An important understanding of vaccine development process performance, and for correctly scaling each process step.
Accelerate your research with an upgradeable, label-free protein analysis platform
A comprehensive tool set for compliance makes the Octet® BLI platform an ideal analytical instrument in regulated environments.
When investigating biological mechanisms and developing new therapeutics, BLI and SPR offer unique advantages
Modern analytical techniques designed for real-time analysis and high-throughput capabilities significantly reduce the time to the discovery
Technologies, Key Considerations, and Applications
Establish specificity, accuracy, precision, linearity and range as stipulated by USP 1032 requirements
Explore the latest methodologies and strategies in the development of future vaccines fighting infectious diseases with label-free approaches
Live Cell Analysis, Advanced Flow Cytometry and Label-Free Binding Analysis
In cell culture-based vaccine manufacturing processes, microbial contamination control and impurity testing are crucial elements of quality control.
Learn more about how virus-neutralizing antibodies have proven to be a key tool in the fight against SARS-CoV-2.
Bioprocess Five Additional Batches of AAV Samples Annually
Learn more about how Octet® systems are used to advance Coronavirus research and vaccine development
Fast, accurate determination of vaccine titre during influenza vaccine manufacture is important in understanding process performance and correctly sca...
Label-free alternative for characterizing protein-protein and drug-protein interactions in standard microtiter plate format
Quantitation assays must show precision, accuracy, linearity, and reproducibility
Unmatched Versatility for Discovery, Development and Quality Control
Developing kinetics binding assays to establish specificity, accuracy, precision, linearity and range as stipulated by USP 1032
For Quantitation and Kinetic Characterization of Human Fc-Region Containing Proteins
Streptavidin is often deployed as the molecule of choice for covalent linking to solid surfaces for ligand binding assays applications.
Design and develop biological assays that conform to USP <1032> for accuracy, precision, linearity and limit of quantitation (LOQ) to be establi...
Designed for a rapid high-throughput quantitation of residual CHO Host Cell Proteins (HCPs) in bioprocessing samples during production and development...
For Quantitation of Whole-Molecule Antibody and Antibody Fragments
REGENXBIO Inc. shares their experience in finding a high-throughput technique for AAV capsid concentration quantification.
The multivalent nature of antibodies can lead to avidity effects that skew binding affinity data. Hear from a protein analytics expert about avoiding...
Simplifying the Characterization of the drug trastuzumab to Kadcyla®️ and Enhertu®️
See the Octet® AAVX Biosensor in comparison to an in-house assay on the Octet BLI platform.
Explore applications of the CHO antibody simultaneous display and secretion technology
Cell surface Nucleocapsid (N) protein may play an important role in host adaptive immunity to SARS-CoV-2
Using Bio-Layer Interferometry Technology, we developed a set of assays to identify antibodies with SARS-CoV-2 reactivity
To validate covalent proximity inducing small molecules with synthetic tumor immunotherapeutic applications
Improve the overall drug discovery process to increase the success rate of preclinical candidates.
Improve the overall drug discovery process to increase the success rate of preclinical candidates
BLI technology for affinity characterization antibodies can benefit critical reagent workflows
Virtual screening of molecular databases and biochemical/biophysical techniques
Discover the new versatile Octet®️ R series and the use of Optimer™️ binders to improve affinity purification of novel biologics
Learn how Octet® BLI works in therapeutic discovery and development, including common challenges and solutions
Developing Methods for Comparability Studies of Therapeutic Monoclonal Antibodies
Orthogonal Analysis Using Ligand Binding Kinetics and Live Cell Binding
Drug development and production is challenging. Avitide, based in Lebanon, New Hampshire, provides on-demand development and supply of high-performanc...
by Proximity Inducing Molecules
Antibody and other protein therapeutics are a major focus in drug discovery pipelines today
Tips collected over the years from customers successful with their equipment grant proposals.
In Lot Release and In-Process Testing of Biologics in GxP Laboratories
Experience the difference of label-free Octet® BLI Systems
Literature references covering a large variety of research areas and applications
Get the Latest Updates, Trends and Developments on Label-free, Stress-Free Solutions for Drug Discovery, Biologics Development and Biomanufacturing.
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