Viral Vectors for Gene Therapy
Single-Use Technologies and Associated Services to Address the Process Development and Productions Needs of Manufacturers of Viral Vectors
Sartorius technologies are ideally suited for the production of viral vaccines, vectors and gene therapies. They allow end-to-end, single-use processing of viruses from process development through to commercial manufacturing at the 2000 L-scale. Manufacturers of virus-related products are benefiting from our unique upstream and downstream technologies, analytics and services including our process development consultancy, cost modelling and process engineering capabilities.
Gene therapy has become one of the most rapidly evolving and promising fields in regenerative medicine and has a wide range of potential applications, such as the treatment of hereditary genetic disorders, cancer and infectious diseases. Gene therapy mainly encompasses the use of a viral vector to introduce an intact gene, either directly into the patient (in vivo) or indirectly via transduction of cells before infusion into the patient (ex vivo), to reconstitute or modify a harmful gene variant.
The growing number of viral vectors used as clinical therapeutics will require scalable commercial upstream and downstream processes to be developed and optimized to ensure that critical quality attributes (CQAs) are retained.
Plasmid DNA (pDNA) is the starting point for the production of various next-generation biopharmaceuticals. However, pDNA molecules are larger and more sensitive than traditional modalities, creating a new set of manufacturing challengesExplore the steps in a typical pDNA purification processUnderstand the hurdles associated with efficient pDNA production, and discover how our solutions can help you overcome them
Explore pDNA Production
Pure, safe, and consistent, USP-NF compliant Recombumin® recombinant albumins support gene therapies from R&D to in-human applications.
Sample media for gene therapy and viral vector vaccinesRequest Your Sample
Learn how we achieved high purity and concentration while maintaining EV critical quality attributes.
A valuable tool for suspension adaptation of viral vector production cell lines, media development and viral vector screening.
A modular bioreactor system for rapid determination of critical parameters, i.e. timing of host cell line transfection or multiplicity of infection.
A single-use bioreactor family and an ideal platform for your flexible manufacturing facility supporting fed-batch and continuous processes.
A membrane adsorber technology ideally suited for the purification of viral vectors.
The right chromatography tools for the right tasks - and the skills to use them.
A unique automated platform for real-time tracking of viral particles and quantification of total intact virus particles.
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