Viral Vaccines & Vectors
The recent global outbreak of coronavirus diseases (COVID-19) caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2) serves as a stark reminder of the imminent threat of unexpected pathogens. We need a deeper understanding of the cellular and molecular mechanisms that drive immune responses against emerging infectious diseases (EIDs). See how Sartorius' innovative, groundbreaking solutions advance and accelerate your discovery and development of new vaccines against viral infections.
Rebecca DuBois, Associated Professor, outlines the advantages of using Sartorius' Octet®️ platform.
Join us for an engaging virtual seminar consisting of two presentations from Public Health England (PHE) and The Pirbright Institute.
In this edition of Research Arc, we explore the latest efforts in developing safe and efficacious therapies against a wide range of viral infections.
Learn about the latest studies highlighting novel strategies and methodologies to accelerate vaccine development to combat infectious disease.
Advanced flow cytometry platform to get from samples to actionable results in record time.
The iQue® Advanced Flow Cytometry Platform can be used for viral research activities such as monitoring host-pathogen interactions, antibody library screening, immune response assessment, epitope mapping, and antibody neutralization studies.
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In the race for a vaccine, accelerating biological insight is critical.
The Incucyte® Live-Cell Analysis System improves productivity with powerful, automated image acquisition. Accelerate your next discovery with a flexible assay platform that accommodates multiple applications simultaneously with multi-plate throughput. Protect your cells and your team, by performing analysis with networked, remote access as your cells remain in the physiologically relevant environment of the incubator.
With automated analysis and a portfolio of reagents, consumables and software specifically designed to detect dynamic immune response, solving biologically relevant questions has never been easier!
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Antibody NeutralizationNeutralizing antibodies have the potential of therapeutic agents.See how a potently neutralizing human monoclonal antibody with post-exposure therapeutic activity against ZIKV infection was developed in a mouse model. - Read more by Long et al. PNAS, 2019
Viral Therapeutics and Vaccine DevelopmentDevelopment of an influenza virus pseudo typed with Ebolavirus glycoprotein to aid therapeutic screening. - Read more by Xiao JH et al. J Virol. 2018 Jan 30;92(4)
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Explore the Entire Host-Pathogen Life Cycle with Advanced Cell Analysis Solutions.
Gaining deeper insights into therapeutic development with in-depth T Cell Characterization.
Detect real-time measurements of cell death based on cell membrane integrity.
Investigate aberrations in apoptotic pathways in intact, living cells.
Understand the mechanisms of immune cell activation, proliferation and regulation.
Advanced flow cytometry platform to get from samples to actionable results in record time. Evaluate cytotoxicity, apoptosis and other biological...
Viral replication and infection assays enable the study of pathogenesis in host cultures and the testing of novel antiviral therapeutics.
Measure signalling pathway activation and activity of promoter driven reporter gene expression in real time.
Real time visualization and fully automated analysis of tumor cell killing.
The Octet® Bio-Layer Interferometry (BLI) platform offers unprecedented time and cost savings during biomolecular interactions analysis. Octet® systems accelerate COVID-19 research, and will help you to:
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Analysis of coronavirus binding to host receptorsAffinity and kinetics of virus-host receptor binding interactions are crucial to understanding viral pathogenesis and therapeutic development approaches. Octet® platforms enable fast and accurate analysis of binding interactions in real-time. - Read More by Walls et al. Cell, 2020
View our complete list of publications on coronavirus research
Studying antibodies from COVID-19 infections and vaccines can provide invaluable information toward therapeutic antibody development
Sartoclear Dynamics® Lab V50 kits: Virus harvesting in one stepKits combining a vacuum filtration unit, Sartolab® RF 50 with a 0.45 µm PES membrane and a filter aid for clarification.
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Vivapure® Virus Purification and Concentration KitsAdenovirus and lentivirus purification kits utilize membrane adsorber technology for fast and safe virus purification.
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Vivaflow®, Vivaspin® and Vivapure® UltrafiltersPerfect solutions for your ultrafiltration needs serving the complete protein ultrafiltration workflow: From concentration and diafiltration of the original protein source, a cell culture supernatant, to final concentration.
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Ergonomics – Pipetting for Your SafetyA basic but repetitive application, therefore ergonomics is key.
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Do you need to dispense large volumes straight from a bottle or tube?To make it easy for you, we offer handy pipette controllers and bottle-top dispensers.
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Octet® quantitation assays are perfect solutions to measure antibody and vaccine titers in your process development samples that provides fast at-line testing capabilities. With a variety of ready-to-use quantitation specific biosensors, a full 96-plate of antibody or vaccine titers can be measured within minutes using the Octet® platform.
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See how Vivaspin® ultrafilter was used in recent Coronavirus related research experiments for concentration of Virus Like Particles (VLPs) and proteins.
Evidence that TMPRSS2 Activates the Severe Acute Respiratory Syndrome Coronavirus Spike Protein for Membrane Fusion and Reduces Viral Control by the Humoral Immune Response. Glowacka et al. Journal of Virology - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3126222/
Expression, purification and crystallization of the SARS-CoV macro domain. Malet et al. Crystallography Journals Online - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2222557/
Structure of the SARS-Unique Domain C From the Bat Coronavirus HKU4. Staup et al. SAGE Journals - https://journals.sagepub.com/doi/full/10.1177/1934578X19849202
Structure, Function, and Antigenicity of the SARSCoV-2 Spike Glycoprotein. Walls et al. Cell- https://doi.org/10.1016/j.cell.2020.02.058
Sample weighing is a commonly occurring step during vaccine research and development, and in pre-clinical phases where the most reliable lab weighing results have the utmost importance. As vaccine research becomes more challenging with the continuous emergence of new diseases and novel safety concerns, higher standards of precision, as well as flexibility and speed, are necessitated during these workflows.
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Cubis®️ II laboratory balances offer customizable hardware and software, modern user interfaces, pharmaceutical and GxP compliance, including data integrity at the highest level of accuracy and precision. With our broad spectrum of solutions and long term expertise, we guarantee the highest level of accuracy, and also support your weighing workflows in a simplified and intuitive manner.
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Ensure your results are from your cells, not contamination. Screen your cultures with our real-time PCR kit for mycoplasma contamination.
Provides rapid detection of total bacteria within 2½ h. For fast and reliable real-time PCR-based detection of bacterial contamination in cell culture...
Reliable aseptic technique for cell culture expansion. A revolutionary closed design that ensures media feed, inoculation, sampling, and transfers are...
Designed for efficient removal of endotoxins, RNase, DNase, microorganisms and particles. Provides the highest safety for your critical cell culture a...
The manually operated Claristep® Filtration System consisting of a station and filter units provides a modern, simple fix for HPLCs demanding needs.
Soak it up right! Pure blotting paper and consistent CN membrane for reproducible results.
Closed Membrane Filtration Systems for Sterility Testing
Our Sterisart® portfolio is easy to use, minimizes the risk of false positives and false negative, meets all regulatory requirements, and provides you with complete confidence in your sterility testing results. We redefine industry standards.
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Sartorius Application Centers are located in Germany, China and the United States. It is your opportunity to experience Sartorius solutions for your specific bioprocess as well as laboratory tasks and applications. By meeting our industry experts you will receive a highly process- and application-specific consultation alongside hands-on tests of our cutting-edge technology.
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