Setting the Standard in AAV Gene Therapy, Together
Adeno-associated virus (AAV) gene therapies have potential to transform the way we treat certain diseases. But to deliver them successfully, robust and cost-effective production is critical.
Bring your therapy to market faster and affordably with end-to-end solutions that deliver reproducible performance and scalability with a simplified path to regulatory approvals.
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Explore AAV gene therapy solutions to simplify progress in every step of your workflow.
Challenge: Suboptimal media handling with risk of contamination from adventitious agents present in media and buffer.
Solution: Simple and fast media preparation and sterile connection
Highlight products supporting fluid management, media and buffer prep
Extractables and leachables testing: Data and support
Sartopore® 2 filter: Sterilizing grade double layer filter 0,45|0,2µm
Virosart® Media: Viral retention for cell culture media
Challenge: Plasmid selection and design process is complex; media and reagents are unoptimized and have high variability during scale-up.
Solution: Design custom plasmid DNA vectors or acquire them off-the-shelf. Optimize viral vector production using our equipment, raw materials, and services.
Highlight products supporting vector engineering and production
Recombumin® recombinant human albumin as a multifunctional excipient, ancillary, and raw material.
FectoVIR® AAV transfection reagent for large-scale AAV manufacturing.
pPLUS® plasmids off-the-shelf AAV Helper & RepCap and custom-engineered plasmids.
HEK media optimized for AAV transfection and production.
Ambr® and Biostat STR® automated high-throughput and commercial-scale bioreactors.
Challenge: Lengthy and manual process optimization during development and scale-up.
Solution: Optimized analytics, including design of experiments (DOE) and analytical chromatography, enable fast and accurate process optimization. Multivariate data analysis (MVDA) ensures robust process control.
Highlight products supporting analytics
MODDE® DOE you can quickly tap into the power of DOE.
SIMCA® MVDA tackle ambitious Omics projects, model complex systems and gain the deep process understanding needed to drive growth.
CIMac™ HPLC analytical columns provide fast and reproducible monitoring and quantitation of Empty/full capsids, aggregates, impurities (DNA, proteins), etc.
Octet® Bio-layer interferometry (BLI) platform rapid quantitation of AAV capsids in bioprocess development for gene therapy.
PATfix® analytical liquid chromatography which can determine full and empty AAV content for process and product yield monitoring.
Achieve high AAV recovery from cell lysates with fast, scalable harvest and clarification solutions.
Highlight products supporting harvest and clarification
Sartoclear® which are cellulose-based depth filters with low virus adsorption.
Sartopore® 2 XLG filter: Double layer filter 0,8ï0,2mm to enhance recovery and high total throughput.
Tangential Flow Filtration (TFF) enables separation and concentration of AAVs in a gentle and efficient way.
Highlight products supporting tangential flow filtration
TFF cassettes: Recommended of 30-100KDa cut off Hydrosart. A cellulose based membrane is a low adsorption filter of viral capsid proteins.
Ambr® Crossflow TFF system for screening conditions using Hydrosart slice 50.
Sartoflow® Smart and Sartoflow® Expert from benchtop to manufacturing TFF systems.
Develop a high-performing chromatography step that removes process- and product-related impurities to achieve a highly pure and potent AAV.
Highlight products supporting capture and polishing
Highlight service to support capture and polishing
Controlled freeze-thaw and validated shipping solutions for confident storage and transportation of sensitive drug substances|products.
Solutions supporting cold chain management
Challenge: Inconsistent filling accuracy, low product recovery, contamination risk.
Solution: Filtration with high performance, yield, and recovery.
Solutions supporting final filtration, fill and finish
To help find the right materials and consumables for your needs, request a sample from our portfolio.
Request Your Sample
Increase AAV titer and particle quality with optimized transfection reagents and plasmids.
Generate high yield and titer with scalable and widely compatible media.
Remove turbidity, increase AAV yield, and scale up easily with high-capacity and low-adsorption filters.
Preserve sterility during connection and disconnection throughout your biomanufacturing process.
Increase viral vector recovery using low adsorption membranes with MWCO ranging 30 to 300kDa, available in closed, presterilized units.
Manage your entire cold chain with confidence – from filling and freezing to shipping, thawing, and dispensing.
Optimize your therapy for larger volumes with a fully scalable, single-use bioreactor.
Achieve a sterile product by using a high-efficiency, low-adsorption, and robust filter to maximize yield.
Protect your product during storage and shipping for sterile filtration, media preparation, sampling, and fluid transfer steps.
Browse AAV gene therapy products by searching or filtering by product type.
Browse additional products, services, and training for AAV gene therapy.
Purify AAV vectors with convective chromatography columns that enable effective empty full capsid separation.
Address regulatory challenges with validation services trusted by the biopharmaceutical industry.
Discover solutions for every step of plasmid DNA manufacturing, from bacteria to final filtration.
Learn how an optimized DSP platform can improve process development timelines and manufacturing complexity in AAV gene therapy.
Your checklist from research and development to clinical and commercial production.
Weigh the pros and cons of bottles and single-use bags with help from our experts.
Learn early PD strategies that enhance clinical-stage production of AAV and LV.
Learn about a workflow for rapid, direct, and label-free quantitation of AAV capsids in crude and purified samples.
See how using suspension HEK cultures can make your scale-up more robust.
Get insight on market trends, needs, and challenges related to AAV, LV, and AdV upstream processing.
Learn more about viral vector purification including chromatography, filtration, and more, along with analytics and market trends.
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