Sartoflow® Smart Small-Scale Benchtop TFF System
Smart and Easy — The TFF System for Process Development
The Sartoflow® Smart is a modular and flexible small-scale TFF benchtop system optimized for ultrafiltration and diafiltration applications used in many downstream processes, such as purification of vaccines, monoclonal antibodies and recombinant proteins. The system is well-suited to laboratory environments for process development and clinical trials as well as small batch cGMP production.
Ideal for membrane surface areas from 50 cm2 to 0.14 m2 with optional customization features
Easy-to-use out of the box with predefined sequences
Low shear 4-piston membrane pump and very compact 20 mL recirculation volume for maximum yield
Excellent Flexibility
The Sartoflow® Smart is a modular and flexible small-scale system with many customization options:
- External diafiltration pump
- Sartocon® Slice 50 cassette holder
- Sensors for pH, conductivity and temperature
- External permeate balance up to 64 kg (vs 7 kg standard)
- Recirculation and/or permeate holder for Flexboy® bags
- IQ/OQ execution package
- Basic qualification test documentation
- cGMP documentation
Intuitive Operation With Predefined Production Sequences
With an intuitive, user-friendly interface, operators can use predefined parameters to automatically run customized sequences for concentration, diafiltration (UF | DF), rinsing, filling, draining and flushing steps.
Pivotal for Process Scalability
The Sartoflow® Smart TFF system is the ideal tool for developers establishing and refining process parameters in scale-up and scale-down studies.
- Low minimum sample volume
- Low minimum recirculation volume
- Easy data access
- Full transferability of process parameters to large-scale systems
Sartoflow® Smart Overview
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Learn More About Sartoflow® Smart
General Specification |
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|---|---|
Weight | ~35 kg (77 lbs.) |
Dimensions | 602 × 440 × 610 mm |
System Specification | |
|---|---|
Membrane Area | 50 cm² , 200, 400 cm², 0.14 m² |
| Recirculation Vessel Volume | PSU vessel with stirrer: 1 L Flexboy® single-use bags: 150 - 1,000 L |
Flow Rate | 1–100 L/h @ 3 bar (43.5 psi) |
Minimum Recirculation Volume | < 20 mL |
Automation Level | Semi automated |
Process Mode (Multi-Use/ Single-Use) | Multi-use |
cGMP Available | Yes |
Max Pressure | 3 bar (43.5 psi) |
Temperature Control | No, monitoring only |
Wetware Specification | |
|---|---|
Tube ID | 1/8" |
Connections | Luer-lock |
Sensors | Pressure (in line: feed, permeate, retentate) Conductivity, pH, temperature ( in PSU vessel) |
