White Paper: Streamlining Affinity Analysis for Accelerated Lead Screening
Introduction
Antibody and other protein therapeutics are a major focus in drug discovery pipelines today. The overall process for developing protein therapeutics encompasses target selection and validation, library screening to generate early candidates (hits), follow-up characterization for lead selection, lead optimization, and clinical candidate selection.
During lead selection, molecules identified as hits are subjected to screening via multiple analytical methods to select a few candidates for progression to the next stage of the development process. This is typically followed by detailed characterization for confirmation of binding and functional activities via biochemical and biophysical analyses.
